Does yaz benefit pmdd

Oral Contraceptive Yaz About competitive with Antidepressants in Treating Premenstrual Dysphoric Disorder, Study Says
02 Sep 2005
Yaz - a dental contraceptive made by the German pharmaceutical company. . . Schering -- is about competitive with antidepressants for treating the signs of premenstrual dysphoric disorder, an intense sort of premenstrual syndrome or pms, as outlined by research scheduled for being published inside the September issue of Obstetrics & Gynecology, AFX/Forbes reports. Kimberly Yonkers, a part professor with the Yale University Med school, and colleagues conducted a double-blind medical study involving 450 women with signs of PMDD at 64 U. buy celebrex online without a prescription S. medical centers. The researchers discovered that 48. 8% of women taking Yaz showed improvement in symptoms, in contrast to 36. 1% of ladies choosing a placebo. Researchers said Yaz was approximately as efficient at reducing PMDD symptoms as serotonin reuptake inhibitors, which can be widely used as antidepressants (AFX/Forbes, 8/31). However, Yaz is more efficient than serotonin reuptake inhibitors for women seeking contraception in addition to charge of PMDD simply because would just take one treatment, Yonkers said (Yale release, 8/30). Yaz, the low-dose version of Scherings FDA-approved contraceptive pill Yasmin, contains ethinyl estradiol and drospirenone which is taken once a day for 24 days as well as four days of placebo to induce a period. Most oral contraceptives are taken for 21 consecutive days as well as one week of placebos (Kaiser Daily Reproductive Health Report, 11/19/04). GlaxoSmithKlines Paxil, Pfizers Zoloft, and Eli Lillys Prozac and Sarafem -- all antidepressants -- are definitely the only drugs licensed by the FDA to help remedy PMDD (Fay Cortez, Bloomberg, 8/31). FDA in November 2004 sent an "approvable letter" to Schering subsidiary Berlex for Yaz. To get FDA approval, Berlex must provide you with the agency with a lot more data to support the clinical good thing about the pills dosing regimen (Kaiser Daily Reproductive Health Report, 11/19/04). NIH estimates that between 3% and 8% of females are afflicted by PMDD throughout their reproductive years (Bloomberg, 8/31).
"Reprinted with permission from http://www. kaisernetwork. org. You will see your entire Kaiser Daily Health Policy Report, search the archives, or sign up to email delivery at http://www. kaisernetwork. org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork. org, a free service on the Henry J. Kaiser Family Foundation . 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.
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And
http://women. webmd. com/PMS/news/20061006/yaz-approved-for-severe-pms
Yaz Approved for Severe PMS
First Contraception Pill Shown Effective for Premenstrual Dysphoric Disorder
By Daniel J. DeNoon
WebMD Medical News
Oct. 6, 2006 -- Yaz is among the most first birth prevention pill to find FDA approval for the treatment of premenstrual dysphoric disorder (PMDD), probably the most severe type of PMS.
The FDA based its action on clinical trial results showing that Yaz cut PMDD symptoms by the majority. Women taking Yaz reported double the improvement in PMDD symptoms as women taking inactive placebo pills.
Yaz improved both emotional and physical symptoms of PMDD, including interpersonal relationships, work productivity, and enjoyment of hobbies and social activities.
Like other oral contraceptives, Yaz uses the female hormones estrogen and progestin. Unlike other versions in the pill, Yaz runs on the kind of progestin thats unique properties. This, plus its 24-day dosing regimen, will help are the cause of its positive influence on PMDD, says Andrea Rapkin, MD, in the news release from Berlex Inc. , the U. S. affiliate of Schering that manufactures Yaz.
"For my PMDD patients who require cure to reduce their symptoms -- as well as a secure and efficient contraceptioncontraception to prevent pregnancypregnancy -- YAZ is an important option that may meet both of themselves care needs in one pill," says Rapkin, professor of obstetrics and gynecology at UCLAs David Geffen Med school.
While most women have some PMS symptoms, PMDD develops when these symptoms are at their hardest. PMDD affects about 5% of girls.
PMDD: PMS Squared
Think of PMDD as PMS squared. Women with PMDD have a minimum of five severe premenstrual symptoms. This can include:
* Feelings of sadness, hopelessness, or worthlessness
* Anxiety or tension
* Unstable mood and frequent crying
* Persistent irritability causing conflict in relationships
* Loss of involvement in usual activities or relationships
* Deficiency of concentration
* Lack of energy
* Adjustments to appetite, possibly including cravings or binge eating
* Sleeping an excessive amount or too little
* Feeling outside of control
* Physical symptoms including breast tenderness, breast swelling, headache, joint/muscle aches, bloating, and fat gain.
At least among the first four symptoms has to be gift for a diagnosis of PMDD. The symptoms occur over the week before a ladies period and resolve inside of a couple of days after her period starts.
Because PMDD can be so severe, doctors usually prescribe antidepressants, antianxiety medications, hormonal treatments, and/or water pills. While doctors purchase other oral contraceptives as treating PMDD, Yaz could be the first drug of this class to take delivery of specific FDA approval for this specific purpose.
The most common unwanted effects seen in women taking Yaz are headache and breast pain.
SOURCES: News release, Berlex Inc. FDA web site. WebMD Medical Reference together with The Cleveland Clinic: "Your Self-help guide to Premenstrual Dysphoric Disorder. " UpToDate.
2006 WebMD, Inc. All rights reserved.
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