GENERIC NAME: celecoxib
Brand: Celebrex
DRUG CLASS AND MECHANISM: Celecoxib is often a
nonsteroidal
antiinflammatory drug (NSAID) utilized to take care of arthritis, pain,
menstrual
cramps, and colonic polyps. Prostaglandins are chemicals that are important
contributors towards the inflammation of arthritis that creates pain, fever, swelling
and tenderness. Celecoxib blocks the enzyme that makes prostaglandins
(cyclooxygenase 2), contributing to lower concentrations of prostaglandins. As being a
consequence, inflammation as well as accompanying pain, fever, swelling and
tenderness are reduced. Celecoxib differs from other NSAIDs as it causes
less inflammation and ulceration of the stomach and intestine (at the very least with
short-term use) as well as doesnt affect the clotting of blood.
NSAIDs have
been found to avoid the development and reduce the length of polyps in patients
using the genetic disease, familial adenomatous polyposis (FAP). In FAP, patients
develop a lot of polyps inside their colons, as well as the polyps invariably
become malignant. The sole cure of FAP is eliminating the entire colon. Celecoxib
is approved as an adjunctive (secondary) treatment among patients with FAP. The
cramping and pain during menstrual periods is because of prostaglandins, and
blocking the production of prostaglandins with celecoxib lessens the cramps and
pain.
GENERIC AVAILABLE: No
PRESCRIPTION: Yes
PREPARATIONS: Capsules: 50, 100, 200, and 400 mg
STORAGE: Capsules really should be stored between 15-30 C (59-86 F).
PRESCRIBED FOR: Celecoxib can be used with the relief of pain, fever,
swelling, and tenderness brought on by osteoarthritis, juvenile arthritis,
rheumatism, and ankylosing spondylitis. Celecoxib does not stop the
progress of either style of arthritis. It reduces the symptoms and signs
of arthritis. Celecoxib qualifies for patients with familial FAP whove not
had their colons removed. Celebrex is also also employed for the relief of acute
pain as well as the pain of menstrual cramps (primary dysmenorrhea).
DOSING: The smallest effective dose ought to be used by each patient.
For
the management of osteoarthritis, the dose usually is 100 mg twice daily or 200
mg like a single dose. nasonex online without a prescription
For rheumatoid arthritis symptoms symptoms, the dose usually is 100 or 200 mg
twice a day.
For acute pain or menstrual cramps, the dose is 400 mg being a single
dose around the first day and then one more 200 mg as needed, then 200 mg
twice daily when needed.
For FAP, the recommended dose is 400 mg twice a day.
DRUG INTERACTIONS: Concomitant by using celecoxib with
aspirin or other
NSAIDs (for instance, ibuprofen, naproxen, etc. ) could raise the occurrence of stomach
and intestinal ulcers. It usually is utilized on low dose aspirin.
Fluconazole (Diflucan) enhances the concentration of celecoxib in the body
by preventing the excretion of celecoxib in the liver. Therefore, treatment
with celecoxib should be initiated at the deepest recommended doses in patients
that are taking fluconazole.
Celecoxib enhances the power of lithium (Eskalith) from the blood by
17% and may promote lithium toxicity. Therefore, lithium therapy needs to be
closely monitored during and after therapy with celecoxib.
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