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Perindopril (Coversyl, Aceon) is a long-acting ACE inhibitor

Indications

* Essential hypertension.
* Stable coronary artery disease: reduction of risk of cardiac events in patients with a history of myocardial infarction and/or revascularization.
* Treatment of symptomatic heart disease or failure.

Dosage and administration

Perindopril should be taken in the morning before food.

For Hypertension

4 mg once daily, then the dose may be increased to 8 mg after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease.

In Australia perindopril arginine is available as Coversyl, the generic form perindopril erbumine is also available. The two formulations are equivalent and may be freely

substituted for each other[1]. In hypertension, the initiation dose is 5 mg perindopril arginine (or 4mg perindopril erbumine) once daily, then the dose may be increased to 10 mg
perindopril arginine (or 8mg perindopril erbumine) after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease.

The Anglo-Scandinavian Cardiac Outcomes Trial showed the benefits of taking the two drugs Coversyl and amlodipine together. The 9000 British patients aged 40 to 79 were involved
in the five-year trial. Half were given the new drug combination, the rest were given traditional drugs. Coversyl and amlodipine were found to be so effective that the trial was
stopped early so that all patients could receive the combination

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