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Avelox Information

Avelox is an antibiotic.

Avelox kills certain bacteria or stops their growth. Avelox is used to treat bronchitis, pneumonia, sinusitis, and certain skin infections.

Avelox Work Information

Avelox contains the active ingredient moxifloxacin hydrochloride, which is a type of medicine known as a quinolone antibiotic. Avelox is used to treat infections of the airways caused by bacteria.

Avelox works by entering bacterial cells and inhibiting the action of two bacterial enzymes, called topoisomerase II (DNA-gyrase) and IV. These enzymes are involved in the replication and repair of bacterial genetic material (DNA); processes that are needed for the bacteria to multiply.

The inhibition of these bacterial enzymes and hence the interference with the bacterial DNA, ultimately results in Avelox killing the bacteria.

Avelox kills a variety of different types of bacteria that cause infections such as bronchitis, pneumonia and sinusitis.

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Special information on Avelox

Most Important Fact about Avelox: Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop taking Avelox except on your prescriber's advice. If you stop taking Avelox too soon, surviving bacteria could cause a relapse.

Avelox precautions if you are pregnant or breastfeeding: Avelox use is not recommended during pregnancy since fluoroquinolones have been reported to cause bone development problems in young animals.

Avelox may pass into breast milk. Breastfeeding mothers should not use Avelox . Seek medical advice from your doctor.

Special warnings about Avelox: Tell your doctor or pharmacist if you are taking any other medicines, including herbal medicines and those bought over the counter, before you start treatment with Avelox .

Avelox must not be taken in by people taking any of the following medicines, as this may increase the risk of abnormal heart rhythms (prolonged QT interval on the heart monitoring trace or ECG):

medicines to treat abnormal heart rhythms, e.g. amiodarone, procainamide, quinidine, disopyramide, sotalol tricyclic antidepressants, e.g. amitriptyline, imipramine certain antipsychotics, e.g. thioridazine, chlorpromazine, sertindole, haloperidol, pimozide the antihistamines astemizole, terfenadine or mizolastine certain antimicrobials, e.g. intravenous erythromycin or pentamidine antimalarials, e.g. halofantrine, chloroquine, quinine cisapride.

Avelox should be used with caution in people who are taking medicines that can reduce the amount of potassium in the blood, as if low blood potassium occurs there may be an increased risk of abnormal heart rhythms. Medicines that can lower blood potassium include the following:

corticosteroids, e.g. beclometasone, prednisolone diuretics, e.g. bendrofluazide, frusemide beta agonist bronchodilators, e.g. salbutamol.

An interval of about six hours should be left between taking Avelox and any of the following:

antacids containing magnesium or aluminium didanosine tablets sucralfate preparations containing iron or zinc.

The manufacturer of this medicine recommends that people who are taking anticoagulant medicines to prevent blood clots, e.g. warfarin, should have their blood clotting time (INR) monitored more frequently while taking Avelox.

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Why Avelox should not be prescribed ?

Avelox should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using Avelox and inform your doctor or pharmacist immediately.